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Pharmacological treatment for BPD is considered as an adjuvant for the psychotherapist, and there is evidence for using it to treat some of the clinical components of the disorder, especially impulsiveness. Moreover, BPD typically co-exists with other psychiatric disorders, such as attention deficit disorder, substance abuse disorder and affective disorders.

Drugs are an important aid for patients suffering from severe BPD, especially during initial phases of treatment. Before using a psychotropic drug, a detailed anamnesis must be conducted, and the therapeutic objective must be appropriately defined to control tolerance and the efficacy of the medications.